The five are among the buildings local advocates has been pushing to landmark ahead of a proposed rezoning of the area.
Of the 16 people who provided testimony at the hearing, including representatives for the owners of four of the five properties, not one person spoke against designation.
Locals and preservationists have been advocating for landmarking the buildings for years.
Each building represents the "best architectural examples of their type in the area," said LPC Chair Sarah Carroll.
In an unexpected development Monday afternoon, the Landmarks Preservation Commission added five Gowanus industrial buildings to the schedule for Tuesday's hearings.
The ASPCA was very popular with Brooklyn’s philanthropists, so when they needed a larger building they received generous donations towards a new facility.